https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Assessing the Effects of Changing Patterns of Inhaled Corticosteroid Dosing and Adherence with Fluticasone Furoate and Budesonide on Asthma Management https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54297 Wed 28 Feb 2024 15:52:17 AEDT ]]> Antagonism of miR-328 increases the antimicrobial function of macrophages and neutrophils and rapid clearance of non-typeable Haemophilus Influenzae (NTHi) from infected lung https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22005 haemophilus influenzae and pharmacological inhibition in mouse and human macrophages augments phagocytosis, the production of reactive oxygen species, and microbicidal activity. Moreover, inhibition of miR-328 in respiratory models of infection, steroid-induced immunosuppression, and smoke-induced emphysema enhances bacterial clearance. Thus, miRNA pathways can be targeted in the lung to enhance host defence against a clinically relevant microbial infection and offer a potential new anti-microbial approach for the treatment of respiratory diseases.]]> Wed 11 Apr 2018 16:14:13 AEST ]]> Inhibiting AKT phosphorylation employing non-cytotoxic anthraquinones ameliorates T<sub>H</sub>2 mediated allergic airways disease and rhinovirus exacerbation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15239 H) 2 and 17 cell activation, airway neutrophilia and phosphoinositide-3-kinase (PI3K) activation. Asthma exacerbations are commonly caused by rhinovirus (RV) and also associated with PI3K-driven inflammation. Anthraquinone derivatives have been shown to reduce PI3K-mediated AKT phosphorylation in-vitro. Objective: To determine the anti-inflammatory potential of anthraquinones in-vivo. Methods: BALB/c mice were sensitized and challenged with crude house dust mite extract to induce allergic airways disease and treated with mitoxantrone and a novel non-cytotoxic anthraquinone derivative. Allergic mice were also infected with RV1B to induce an exacerbation. Results: Anthraquinone treatment reduced AKT phosphorylation, hypoxia-inducible factor-1α and vascular endothelial growth factor expression, and ameliorated allergen- and RV-induced airways hyprereactivity, neutrophilic and eosinophilic inflammation, cytokine/chemokine expression, mucus hypersecretion, and expression of TH2 proteins in the airways. Anthraquinones also boosted type 1 interferon responses and limited RV replication in the lung. Conclusion: Non-cytotoxic anthraquinone derivatives may be of therapeutic benefit for the treatment of severe and RV-induced asthma by blocking pro-inflammatory pathways regulated by PI3K/AKT.]]> Wed 11 Apr 2018 15:17:09 AEST ]]> Activation of olfactory receptors on mouse pulmonary macrophages promotes monocyte chemotactic protein-1 production https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15242 Tue 11 Jun 2019 11:55:23 AEST ]]> Antagonism of microRNA-126 suppresses the effector function of TH2 cells and the development of allergic airways disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7560 Sat 24 Mar 2018 08:42:06 AEDT ]]> Inhibition of house dust mite-induced allergic airways disease by antagonism of microRNA-145 is comparable to glucocorticoid treatment https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15235 H2 cytokine production, and airway hyperresponsiveness. The anti-inflammatory effects of miR-145 antagonism were comparable to steroid treatment. Conclusion: Our study highlights the importance of understanding the contribution of miRNAs to pathogenesis of human allergic disease and their potential as novel anti-inflammatory targets.]]> Sat 24 Mar 2018 08:21:45 AEDT ]]> The emerging role of microRNAs in regulating immune and inflammatory responses in the lung https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16016 Sat 24 Mar 2018 08:19:30 AEDT ]]> Production and differentiation of myeloid cells driven by proinflammatory cytokines in response to acute pneumovirus infection in mice https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20418 Sat 24 Mar 2018 08:00:53 AEDT ]]> A randomized, cross-over study comparing critical and overall errors, learning time, and preference of the ELLIPTA versus BREEZHALER dry powder inhalers in patients with asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54653 Fri 08 Mar 2024 09:54:06 AEDT ]]>